• Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-30)
      Background We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear.<p> <p>Methods In this exploratory sub-study of the ASSAIL-MI trial, we examined leukocyte differential counts and their relation to myocardial salvage and peak troponin T (TnT) in STEMI ...
    • LIGHT/TNFSF14 is increased in patients with type 2 diabetes mellitus and promotes islet cell dysfunction and endothelial cell inflammation in vitro 

      Halvorsen, Bente; Santilli, Francesca; Scholz, Hanne; Sahraoui, Afaf; Gulseth, Hanne Løvdal; Wium, Cecilie; Lattanzio, Stefano; Formoso, Gloria; Di Fulvio, Patrizia; Otterdal, Kari; Retterstøl, Kjetil; Holven, Kirsten Bjørklund; Gregersen, Ida; Stavik, Benedicte; Bjerkeli, Vigdis; Michelsen, Annika; Ueland, Thor; Liani, Rossella; Davi, Giovanni; Aukrust, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-07-15)
      Aims/hypothesis: Activation of inflammatory pathways is involved in the pathogenesis of type 2 diabetes mellitus. On the basis of its role in vascular inflammation and in metabolic disorders, we hypothesised that the TNF superfamily (TNFSF) member 14 (LIGHT/TNFSF14) could be involved in the pathogenesis of type 2 diabetes mellitus. <p>Methods: Plasma levels of LIGHT were measured in two cohorts of ...
    • Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study 

      Ratajczak-Tretel, Barbara; Lambert, Anna Tancin; Al-Ani, Riadh Ibrahim Mahmud; Arntzen, Kathrine Grønning; Bakkejord, Grete; Bekkeseth, Hanna Marie Otterholt; Bjerkeli, Vigdis; Eldøen, Guttorm; Gulsvik, Anne Kristine; Halvorsen, Bente; Høie, Gudrun; Ihle-Hansen, Hege Beathe; Ihle-Hansen, Håkon; Ingebrigtsen, Susanne; Kremer, C.; Krogseth, Siv Bohne; Kruuse, C.; Kurz, Martin; Nakstad, Ingvild; Novotny, Vojtech; Næss, Halvor; Qazi, Rehman Ul-Haq; Rezaj, M.K.; Rørholt, Dag Marius Nitschke; Steffensen, Linn Hofsøy; Sømark, Jesper Norsted; Tobro, Håkon; Truelsen, T.C.; Wassvik, L.; Ægidius, K.L.; Atar, Dan; Aamodt, Anne Hege (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)
      Background - Atrial fibrillation (AF) detection and treatment are key elements to reduce recurrence risk in cryptogenic stroke (CS) with underlying arrhythmia. The purpose of the present study was to assess the predictors of AF in CS and the utility of existing AF-predicting scores in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study.<p> <p>Method - The NOR-FIB study was an international ...